Portfolio

Farouk Osman

Early-career clinical researcher in cardiology & cardio-oncology

Three years of research at a cardiac-MRI company: preparing data, running analyses, creating visualizations used for published findings.

Open to clinical research roles · US/MENA/EU

Scroll for a sample clinical dashboard

Work published or presented in Diagnostics, J. Cardiovascular Magnetic Resonance, Cardio-Oncology, SCMR Scientific Sessions & Pediatric Academic Societies

Sample dashboard

A clinical dashboard, built on sample data

A cardio-oncology surveillance view of the kind my analyses feed into: a simulated cohort of 480 patients on cancer therapy, scored by a strain-based risk model. Every number here is synthetic. Click anywhere on it to see the analyses behind it.

Open the analyses page. Sample dashboard summary: 480 simulated patients, 23.1 percent cardiotoxicity, model AUC 0.78 versus 0.54 for LVEF alone. Explore every analysis

Simulated data generated for this portfolio. No patient information is shown; the model and cohort are illustrations of the methods, not study results.

Farouk Osman

About

Hi, I’m Farouk.

Portrait of Farouk Osman

I’m 26, currently living in Cary, North Carolina, and early in my career in clinical research. I graduated summa cum laude from NC State with a B.S. in Human Biology, then spent over three years at MyoCardial Solutions, a cardiac-MRI company, working on research in cardiology and cardio-oncology.

Most of that time was spent handling clinical data: cardiac MRI, biomarkers, ECG, exercise testing, and medication records from heart-failure, congenital, transplant, and cancer-treatment cohorts. Working closely with clinicians, cardiologists, researchers, and business teams at a startup, I learned how to turn a clinical question into an analysis plan, how to create meaningful results, and how to explain it clearly to those who will use it.

A large part of my work focused on patients treated for cancer. I developed and validated timing metrics from heart-muscle strain that help flag cardiac injury from chemotherapy early, with precision comparable to or even exceeding standard measures, which is the trend I want to continue pursuing.

Education
B.S. Human Biology, NC StateSumma Cum Laude · GPA 3.91 · Dean’s List every semester
Research
3+ years, 10+ studiesCardiology and cardio-oncology
Publications
8 co-authoredPlus 1 acknowledgment on a published paper
Languages
English, Egyptian ArabicFluent · conversational
Beyond the work Bassist, traveler, and a routine built around health Touring the East Coast with Stan y Denghy, 15 countries and counting, and what my days look like outside of work. Step inside

About / Beyond the work

Life outside of work

Music, travel, the everyday routines that keep me balanced, and a game I made. This is the part of me that does not fit on a résumé.

Spotlight
Aceitunaypan, official music video (clip) Watch the full video on YouTube

Stan y Denghy

Bassist · since the summer of 2021

Alternative Latin funk & reggae, sung in Spanish

Stan y Denghy pairs an “old-school” taste in music with inspiration from across the globe. The band was started by friends of mine who immigrated from Venezuela as teens, and with bandmates from such diverse backgrounds we also draw on African, Arabic, and American music. The result is a blend of cultures with a vintage feel that people can dance to while they reminisce.

I picked up the bass in the summer of 2021, and it quickly turned into a deep passion. Before long I was touring the East Coast with my band, Stan y Denghy, and we released an album together.

I have also played bass for artists including lesthegenius, KATA, Finesse the Phantom, and Cherri May, recorded on a number of released tracks, and helped put together shows for fundraisers. It has always been purely a hobby, and my favorite part is being able to focus on a craft and perform it for others.

A lot of hard work made this happen, but anything is possible when you love what you do.

On the road

  1. New York City
  2. Richmond
  3. Chapel Hill
  4. Atlanta
  5. Miami
  6. and many more

Lately I have put music on the back burner to focus on my career, but I still practice to keep my mind sharp.

Stan y Denghy
My second show at Cat’s Cradle, Chapel Hill, NC
Playing a lesthegenius set, Raleigh, NC
First time performing a song I wrote, Raleigh, NC
Boone, NC
Live on stage
House show, Raleigh, NC
Late-night rehearsal

Experience

Where I’ve worked

Three-plus years of cardiology and cardio-oncology research at a cardiac-MRI company, built on earlier lab and clinic work.

Clinical Data Scientist / Clinical Data Research Analyst

MyoCardial Solutions, Inc. · Morrisville, NC · Full-time

Aug 2022 – Dec 2025Most relevant

  • Reported directly to the Chief Clinical Officer and handled the analysis for 10+ cardiology and cardio-oncology studies, from research question and statistical analysis plan through final results.
  • Developed and validated three timing-based myocardial function metrics from F-SENC strain curves. They were implemented in production software and included as supplemental analyses in the PREFECT cardiotoxicity study.
  • Analyzed data from 3,000+ patients spanning cardiac MRI, biomarkers, respiratory and fitness metrics, ECG, and medications, across heart-failure, cardiotoxicity, congenital, transplant, ischemia, and PVC cohorts.
  • Supported FDA-regulated software releases: validated production algorithms, including the Gaussian-smoothing step, ran bulk script validation, and tested the interface in seven languages.
  • Prepared 3D heart-model and analysis packages for 200+ patients supporting CorInnova cardiac assist device research.
  • Reviewed LGE scans to identify infarcts for studies, and built 3D heart models from 2D slices in MevisLab.
  • An internal study linking ejection-fraction and stroke-volume thresholds to outcomes identified an understudied group, mostly older women with normal EF but low stroke volume and higher diuretic use, confirmed by ANOVA.

Featured research

Catching chemotherapy heart damage earlier

Chemotherapy can quietly injure the heart, and ejection fraction, the standard measure, often drops only after the damage is done. At MyoCardial Solutions I developed and validated three metrics that read the shape and timing of cardiac strain curves to surface that injury sooner. They are implemented in production software and were included as supplemental analyses in the PREFECT cardiotoxicity study.

Regional myocardial strain curves with a median curve, illustrating F-SENC temporal strain data

From noisy strain curves to validated biomarkers

Every F-SENC scan produces a temporal strain curve for each myocardial segment. I built a reproducible pipeline that smooths the raw curves with a Gaussian-process method (validated against the Savitzky-Golay filter), rejects non-physiologic curves, and computes three complementary measures of myocardial timing and coordination.

  • 0.75 / 0.74AUC for SI / SD-TPS, cardiotoxicity detection
  • 73–90%accuracy across HF stages A–D & cardiotoxicity
  • p < 0.0001between-group separation (Kruskal-Wallis)
  • 200+patients validated (PREFECT study)

The three metrics

Two panels of strain curves: synchronous curves tightly bundled versus dyssynchronous curves spread apart

Synchronicity index (SI)

SI is a Spearman correlation of every regional strain curve against the heart’s median curve. A value near 1.0 means the whole ventricle contracts and relaxes together; lower values reveal mechanical dyssynchrony.

  • Captures dyssynchrony that ejection fraction alone can miss
  • Restricted to a physiologic observation window to avoid noisy curve tails
  • Computed with SciPy across longitudinal and circumferential segments

Published in

Lenihan D, Whayne J, Osman F, et al. Myocardial strain measurements obtained with fast-strain-encoded cardiac magnetic resonance for the risk prediction and early detection of chemotherapy-related cardiotoxicity compared to left ventricular ejection fraction. Diagnostics. 2025;15(15):1948.

Impact: F-SENC strain, including these timing metrics, identified patients at risk for chemotherapy-related cardiotoxicity and detected subclinical dysfunction with higher sensitivity than LVEF, supporting earlier cardio-oncology risk stratification and monitoring.

Read the paper (DOI)

Figures are original, simulated illustrations of the published methods; they do not display patient data or any confidential material.

Publications

Published & presented work

Papers and conference abstracts I co-authored in cardiac MRI, ordered by my authorship contribution, with my name in bold. Much of this work is in cardio-oncology: chemotherapy-related cardiotoxicity and cardiac surveillance in childhood cancer survivors.

  • 8co-authored
  • 1acknowledged
  • 1related preprint

  1. 2025Myocardial strain via fast-strain-encoded CMR for risk prediction and early detection of chemotherapy-related cardiotoxicity vs. LVEF (PREFECT)Diagnostics · 15(15):1948Cardio-oncologyJournal article

    Lenihan D, Whayne J, Osman F, Rivero R, Montenbruck M, Schwarz AK, Kelle S, Wülfing P, Dent S, Andre F, Frey N, Korosoglou G, Steen H.

    Showed F-SENC CMR can identify patients at risk for chemotherapy-related cardiotoxicity and detect subclinical dysfunction with higher sensitivity than LVEF, improving early cardio-oncology risk stratification.

    View publication (DOI)
  2. 2023Novel temporal strain parameters to assess dyssynchrony using fSENC in congenital heart diseaseSCMR Scientific SessionsAbstract

    Dodeja AK, Whayne J, Osman F, Trask E, Toro-Salazar OH.

    Evaluated novel fSENC-derived temporal strain parameters for detecting myocardial dyssynchrony in congenital heart disease, enabling more detailed assessment of abnormal myocardial mechanics.

    Search for this paper
  3. 2026Abnormal myocardial strain by strain-encoding imaging is prevalent in pediatric heart-transplant recipients with preserved LVEFSCMR Scientific Sessions · JCMR 28(S1)Abstract

    Lee M, Hor KN, Osman F, Buddhavarapu A, Jacobs H, Gunsaulus M, Casto TC, et al.

    Found abnormal myocardial strain despite preserved LVEF in pediatric heart-transplant recipients, supporting SENC-CMR as a more sensitive tool for transplant surveillance.

    Search for this paper
  4. 2023Identification of subclinical myocardial dysfunction by fastSENC cardiac MRI in cardio-oncology patientsPediatric Academic Societies · Poster 204Cardio-oncologyAbstract

    Toro-Salazar OH, Ruiz TL, Whayne J, Osman FN, Orsey A, Trask E, Dodeja A.

    Demonstrated the feasibility of fastSENC CMR for identifying subclinical myocardial dysfunction in pediatric cardio-oncology patients exposed to cardiotoxic therapy, supporting detection beyond ejection fraction.

    Search for this paper
  5. 2024Evaluation of segmental strain derived from strain-encoded MR (SENC) on a wide-bore 0.55T magnetJ. Cardiovascular Magnetic Resonance · 26(S1):101020Abstract

    Heyniger JL, Liu Y, Chandrasekaran P, Osman F, Nair N, Osman N, et al.

    Supported validation of SENC-derived segmental strain on a wide-bore 0.55T platform, broadening access to strain imaging for patients who benefit from low-field or wider-bore CMR.

    View publication (DOI)
  6. 2025Effectiveness of SENC-CMR in detecting subclinical cardiotoxicity in childhood cancer survivors treated with anthracyclinesJ. Cardiovascular Magnetic Resonance · 27(S1):101173Cardio-oncologyAbstract

    Toro-Salazar OH, Trask EH, Berthod TH, Whayne J, Osman FN, Dodeja AK, Lorenzoni RP, Brimacombe M.

    Evaluated SENC-CMR for detecting subclinical cardiotoxicity in childhood cancer survivors, supporting strain imaging as a more sensitive method than conventional functional measures for early surveillance.

    View publication (DOI)
  7. 2026Longitudinal CMR by strain encoding in Duchenne muscular dystrophy detects abnormal strain and progressive cardiomyopathySCMR Scientific Sessions · JCMR 28(S1):102175Abstract

    Hor KN, Tonnis R, Jacobs H, Buddhavarapu A, Lee M, Gunsaulus M, Osman F.

    Showed strain abnormalities detectable in Duchenne muscular dystrophy despite preserved ejection fraction, supporting SENC-CMR for earlier cardiomyopathy assessment.

    Search for this paper
  8. 2025Feasibility of strain-encoded magnetic resonance at 0.55TJ. Cardiovascular Magnetic Resonance · 27(1):101870Journal article

    Heyniger JL, Liu Y, Nair N, Chandrasekaran P, Binzel K, Kumar V, Bansal SS, Tani D, Osman F, Yildiz VO, Varghese J, Han Y, Simonetti OP.

    Demonstrated SENC imaging is feasible at 0.55T with good agreement for global strain versus 1.5T, supporting low-field CMR as a pathway to more accessible cardiac strain imaging.

    View publication (DOI)
  9. 2025A pilot exercise intervention evaluating cardiorespiratory fitness in modulating cardiotoxicity among childhood cancer survivorsCardio-Oncology · 11:88Cardio-oncologyAcknowledged

    Toro-Salazar OH, Pescatello LS, Mah ML, et al. Farouk Osman, BS, is acknowledged for analysis and figure preparation on segmental strain.

    Explored whether cardiorespiratory fitness and a structured aerobic program influence cardiotoxicity risk and myocardial strain in anthracycline-exposed survivors.

    View publication (DOI)
  10. 2025Impact of a 16-week fitness program on cardiotoxicitymedRxiv (preprint)Cardio-oncologyAcknowledged · preprint

    Toro-Salazar OH, Pescatello LS, Mah ML, et al. Farouk Osman, BS, is acknowledged for analysis and figure preparation on segmental strain.

    Preprint evaluating exercise, cardiorespiratory fitness, and myocardial strain in anthracycline-exposed childhood cancer survivors.

    View preprint (DOI)

Ordered by authorship seniority; the Diagnostics article is my most senior peer-reviewed authorship. Acknowledgments credit analysis and figure work, and the medRxiv preprint is an earlier version of the Cardio-Oncology paper.

Analyses

How I approach the data

The methods I used in research and what each one tells a clinician, the pipelines I built, and a plotting tool I made along the way. Figures use simulated data for illustration only and do not represent real patients or study results.

Click a figure to see what it shows and how I used it. All figures use simulated data.

ROC curves for three models with areas under the curve of 0.93, 0.86 and 0.74
Illustrative

Model discrimination (ROC)

Comparing diagnostic models by area under the curve.

Logistic regression · ROC / AUC
Precision-recall curves for a strain plus clinical model and an LVEF-only model against outcome prevalence
Illustrative

Precision-recall curve

How well a model finds a less common outcome, beyond what AUC shows.

Machine learning · PR / AP
Two by two confusion matrix beside bars for sensitivity, specificity, PPV, NPV, F1 score and accuracy
Illustrative

Confusion matrix & threshold metrics

Sensitivity, specificity, PPV, NPV, F1, and accuracy at a chosen cutoff.

Machine learning · Classification
Kaplan-Meier survival curves comparing two strata with censoring marks and a log-rank p value
Illustrative

Survival analysis (Kaplan-Meier)

Time-to-event between two strata, with a log-rank test.

Survival · Log-rank
Forest plot of adjusted hazard ratios with 95 percent confidence intervals for six predictors
Illustrative

Hazard ratios (forest plot)

Adjusted hazard ratios with 95% confidence intervals.

Survival · Hazard ratios
Two line charts showing strain falling at three months and LVEF falling later in patients who develop cardiotoxicity
Illustrative

Longitudinal imaging trajectories

Strain and ejection fraction across follow-up visits, with 95% CIs.

Longitudinal · Repeated measures
Bland-Altman plot showing agreement between two measurement methods with bias and limits of agreement
Illustrative

Method agreement (Bland-Altman)

Bias and limits of agreement between two methods.

Method validation
Scatter plot of strain magnitude against MyoHealth with a regression line and correlation coefficients
Illustrative

Correlation & regression

Strength and direction of a relationship, with Pearson and Spearman.

Association · Regression
Heat map of Spearman correlations between imaging, clinical and risk-score variables
Illustrative

Correlation matrix (Spearman)

How imaging, clinical, and risk variables move together.

Association · Heat map
Grouped boxplot of a biomarker across four heart-failure classes with individual data points
Illustrative

Group comparison (boxplots)

Distributions across clinical groups with raw data shown.

Group comparison
Overlaid histograms with kernel density estimates for two outcome groups
Illustrative

Distributions (histogram + KDE)

Distribution of a measure across outcome groups.

Exploratory analysis
Bar chart of cardiotoxicity rates across three treatment regimens with a chi-square statistic
Illustrative

Chi-square test of association

Cardiotoxicity rates compared across treatment regimens.

Group comparison · χ²

Testimonials

What colleagues say

Recommendations from people I’ve worked with, in their own words, shared with their permission.

Farouk joined Myocardial Solutions Inc. as a Clinical Data Scientist and quickly became one of the people I relied on most, reporting to me directly while owning end-to-end analysis for more than seven cardiology and cardio-oncology studies.1,2 His technical range is rare for someone early in their career: he built reproducible Python pipelines for everything from ROC/AUC and survival analysis to Bland-Altman agreement testing, developed and verified novel timing-based myocardial function metrics that were implemented in commercial software, and provided key validation to support FDA-clearance. I was impressed as to how effectively he paired that rigor with modern AI-assisted workflows to accelerate research, reporting, and analysis while maintaining accuracy and clinical applicability. Beyond the analytics, Farouk communicates complex findings clearly to clinicians and non-technical stakeholders, builds trust, and brings a curiosity and work ethic that make him a strong fit for any team in clinical data research or a client-facing medical role, and I recommend him without reservation.

References cited (2)
  1. Lenihan D, et al. Myocardial strain measurements obtained with fast-strain-encoded cardiac magnetic resonance for the risk prediction and early detection of chemotherapy-related cardiotoxicity compared to left ventricular ejection fraction. Diagnostics. 2025;15:1948. doi:10.3390/diagnostics15151948
  2. Heyniger JL, et al. Feasibility of strain-encoded magnetic resonance at 0.55T. J Cardiovasc Magn Reson. 2025;27:101870. doi:10.1016/j.jocmr.2025.101870
Jimmy Whayne Chief Clinical Officer, MyoCardial Solutions Incorporated

I had the pleasure of working closely with Farouk Osman on the MyoStrain application, where we collaborated on retrieving clinical cases from studies and validating critical timing metrics of Myocardium. Farouk consistently demonstrated a level of dedication that went beyond what was expected — he would dig into edge cases and inconsistencies until every metric was thoroughly verified. His problem-solving instinct was one of his standout qualities; whenever we hit a roadblock in data validation, Farouk was the first to propose a practical path forward. He is the kind of teammate who elevates the quality of the entire project simply by being involved, and I would recommend him without hesitation.

Magda Sharaf Testing Team Leader, Intixel

Have we worked together?

I would love to add your perspective. Reviews come straight to me, and I confirm with you before anything is published.

What’s next

Where I’m headed

Three years in cardiology and cardio-oncology research showed me where I want to grow. Oncology is moving quickly, with new therapies and diagnostics reaching patients all the time, and each one needs careful evidence behind it on both efficacy and safety. These are the areas I want to learn next.

Oncology research

Cancer-treatment cohorts are where much of my research already sat: anthracycline and radiation exposure, childhood cancer survivors, and treatment-related heart risk. I want to go further into oncology trials and outcomes, where the endpoints are response, progression, and survival.

  • Building on cardio-oncology

Regulatory affairs

I have worked to regulated standards, validating algorithms and testing releases of FDA-regulated cardiac software. I want to learn how that works in oncology, where evidence requirements and approval pathways shape what reaches patients.

  • Have: device V&V
  • Learning: oncology regulatory

EMR & real-world data

Clinical records are messy, and making them answer a research question is a skill of its own. I built a pre-screening pipeline over synthetic EMR-style records and want to work with real-world oncology data next.

  • EMR pre-screening
  • Data manipulation

Precision oncology & genetics

Cancer care is increasingly defined at the molecular level, with biomarker-defined subgroups and targeted therapy. My human-biology background is a starting point, and the genetic components of oncology are an area I am actively exploring.

  • Actively learning

The first three build on work I have done. The last is a direction I am deliberately building toward rather than experience I already have.

Quick answers

What does cardio-oncology research involve?

Cardio-oncology sits between cancer care and cardiology. Treatments such as anthracyclines, HER2-targeted therapy, and chest radiation can damage the heart, so researchers measure whether that is happening, how early it can be detected, and which patients are most at risk. My part in that work was preparing clinical and imaging data, running the analyses, and helping turn the results into findings clinicians and reviewers could use.

What is cancer-therapy cardiotoxicity, and why is it monitored?

Cardiotoxicity is heart injury caused by cancer treatment. It matters because survival from cancer keeps improving, so the heart effects of treatment increasingly shape long-term outcomes. The traditional measure, left ventricular ejection fraction, often drops once meaningful damage has occurred. Strain imaging and related biomarkers can reveal dysfunction earlier, which is what my published work in the PREFECT study and in childhood cancer survivors examined.

What kinds of clinical data have you worked with?

Cardiac MRI and DICOM imaging, biomarkers, ECG, cardiopulmonary exercise testing, medication records, and patient outcomes, from more than 3,000 patients across heart-failure, cardiotoxicity, congenital, transplant, ischemia, and PVC cohorts. I also built a pre-screening pipeline that reads synthetic EMR-style records to find patients eligible for clinical trials.

Which analyses have you run?

Diagnostic accuracy (ROC and AUC, sensitivity, specificity, precision-recall), Kaplan-Meier survival analysis with hazard ratios and forest plots, Bland-Altman agreement for validating a new measurement against an established one, logistic regression, ANOVA, chi-square, and parametric and nonparametric group comparisons, mostly in Python with MySQL.

What regulatory experience do you have?

At MyoCardial Solutions I validated production algorithms, ran algorithm QA and bulk script validation, and tested the software interface in seven languages to support release readiness for FDA-regulated cardiac imaging software. I also wrote statistical analysis plans and prepared manuscript-ready analyses and figures. Growing that regulatory experience in oncology is one of my goals.

What roles are you looking for, and where are you based?

I am based in Cary, North Carolina, near Raleigh, Durham, and Research Triangle Park, and I am open to relocation and to remote work. I am looking for early-career roles in clinical research, especially in oncology and cardiology, where I can keep working with clinical data and learn new skills to help further my career. The contact page reaches me directly.

Contact

Get in touch

If you’re hiring for a clinical research role or want to talk about my work, send a note or ask me to call. I usually reply within one business day.

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Connect

linkedin.com/in/farouk-osman github.com/FaroukN-Osman

Cary, North Carolina · open to relocation & remote